Makela, HI and De Vita, E and Grohn, OHJ and Kettunen, MI and Kavec, M and Lythgoe, M and Garwood, M and Ordidge, R and Kauppinen, RA (2004) B-0 dependence of the on-resonance longitudinal relaxation time in the rotating frame (T-1p) in protein phantoms and rat brain in vivo. MAGN RESON MED , 51 (1) 4 - 8.
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Abstract
On-resonance longitudinal relaxation time in the rotating frame (T-1p) has been shown to provide unique information during the early minutes of acute stroke. In the present study, the contributions of the different relaxation mechanisms to on-resonance T-1p relaxation were assessed by determining relaxation rates (R-1p) in both protein phantoms and in rat brain at 2.35, 4.7, and 9.4 T. Similar to transverse relaxation rate (R-2), R-1p increased substantially with increasing magnetic field strength (B-0). The B-0 dependence was more pronounced at weak spin-lock fields. In contrast to R-1p, longitudinal relaxation rate (R-1) decreased as a function of increasing B-0 field. The present data argue that dipole-dipole interaction forms only one pathway for T-1p relaxation and the contributions from other physicochemical factors need to be considered. (C) 2003 Wiley-Liss, Inc.
| Type: | Article |
|---|---|
| Title: | B-0 dependence of the on-resonance longitudinal relaxation time in the rotating frame (T-1p) in protein phantoms and rat brain in vivo |
| Keywords: | T-1p, relaxation, dipole-dipole interaction, brain, T-1-RHO RELAXATION, CEREBRAL-ISCHEMIA, PROTON-EXCHANGE, SUSCEPTIBILITY CONTRAST, MAGNETIZATION-TRANSFER, TRANSVERSE RELAXATION, CHEMICAL-EXCHANGE, CROSS-RELAXATION, NMR RELAXATION, WATER PROTONS |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Metabolism and Experimental Therapeutics UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering |
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