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B-0 dependence of the on-resonance longitudinal relaxation time in the rotating frame (T-1p) in protein phantoms and rat brain in vivo

Makela, HI; De Vita, E; Grohn, OHJ; Kettunen, MI; Kavec, M; Lythgoe, M; ... Kauppinen, RA; + view all (2004) B-0 dependence of the on-resonance longitudinal relaxation time in the rotating frame (T-1p) in protein phantoms and rat brain in vivo. MAGN RESON MED , 51 (1) 4 - 8.

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Abstract

On-resonance longitudinal relaxation time in the rotating frame (T-1p) has been shown to provide unique information during the early minutes of acute stroke. In the present study, the contributions of the different relaxation mechanisms to on-resonance T-1p relaxation were assessed by determining relaxation rates (R-1p) in both protein phantoms and in rat brain at 2.35, 4.7, and 9.4 T. Similar to transverse relaxation rate (R-2), R-1p increased substantially with increasing magnetic field strength (B-0). The B-0 dependence was more pronounced at weak spin-lock fields. In contrast to R-1p, longitudinal relaxation rate (R-1) decreased as a function of increasing B-0 field. The present data argue that dipole-dipole interaction forms only one pathway for T-1p relaxation and the contributions from other physicochemical factors need to be considered. (C) 2003 Wiley-Liss, Inc.

Type:Article
Title:B-0 dependence of the on-resonance longitudinal relaxation time in the rotating frame (T-1p) in protein phantoms and rat brain in vivo
Keywords:T-1p, relaxation, dipole-dipole interaction, brain, T-1-RHO RELAXATION, CEREBRAL-ISCHEMIA, PROTON-EXCHANGE, SUSCEPTIBILITY CONTRAST, MAGNETIZATION-TRANSFER, TRANSVERSE RELAXATION, CHEMICAL-EXCHANGE, CROSS-RELAXATION, NMR RELAXATION, WATER PROTONS
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Metabolism and Experimental Therapeutics
UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering

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