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Acute changes in MRI diffusion, perfusion, T<inf>1</inf>, and T<inf>2</inf> in a rat model of oligemia produced by partial occlusion of the middle cerebral artery.
Magnetic Resonance in Medicine
Oligemic regions, in which the cerebral blood flow is reduced without impaired energy metabolism, have the potential to evolve toward infarction and remain a target for therapy. The aim of this study was to investigate this oligemic region using various MRI parameters in a rat model of focal oligemia. This model has been designed specifically for remote-controlled occlusion from outside an MRI scanner. Wistar rats underwent remote partial MCAO using an undersize 0.2 mm nylon monofilament with a bulletshaped tip. Cerebral blood flow (CBF(ASL)), using an arterial spin labeling technique, the apparent diffusion coefficient of water (ADC), and the relaxation times T1 and T2 were acquired using an 8.5 T vertical magnet. Following occlusion there was a decrease in CBF(ASL) to 35 ± 5% of baseline throughout the middle cerebral artery territory. During the entire period of the study there were no observed changes in the ADC. On occlusion, T2 rapidly decreased in both cortex and basal ganglia and then normalized to the preocclusion values. T1 values rapidly increased (within approximately 7 min) on occlusion. In conclusion, this study demonstrates the feasibility of partially occluding the middle cerebral artery to produce a large area of oligemia within the MRI scanner. In this region of oligemic flow we detect a rapid increase in T1 and decrease in T2. These changes occur before the onset of vasogenic edema. We attribute the acute change in T2 to increased amounts of deoxyhemoglobin; the mechanisms underlying the change in T1 require further investigation. (C) 2000 Wiley-Liss, Inc.
|Title:||Acute changes in MRI diffusion, perfusion, T<inf>1</inf>, and T<inf>2</inf> in a rat model of oligemia produced by partial occlusion of the middle cerebral artery|
|UCL classification:||UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Brain Repair and Rehabilitation
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of BEAMS
UCL > School of BEAMS > Faculty of Engineering Science
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