Karamichos, D;
Skinner, J;
Brown, R;
Mudera, V;
(2006)
External loading determines specific ECM genes regulation.
In:
European Cells and Materials.
(pp. 10 - 10).
![[thumbnail of v011supp03a10.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/application_pdf.png) Preview |
PDF
v011supp03a10.pdf Available under License : See the attached licence file. Download (71kB) |
Abstract
Bio artificial matrices embedded with cells are simulated in bioreactors to facilitate ECM production. As cells attach, they develop forces, which are dependent on cell type and matrix stiffness. External forces (i.e strain), however, are critical for tissue homeostasis and elicit specific cellular responses, such as gene expression and protein production. Collagen Type I is a widely used scaffold in Tissue engineering. The aim of this study was to study the mechanical and molecular responses, of different cell types to increasing collagen substrate stiffness.
Archive Staff Only
 |
View Item |
