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THE METABOLITES OF NITRIC-OXIDE IN SICKLE-CELL DISEASE

REES, DC; CERVI, P; GRIMWADE, D; ODRISCOLL, A; HAMILTON, M; PARKER, NE; PORTER, JB; (1995) THE METABOLITES OF NITRIC-OXIDE IN SICKLE-CELL DISEASE. BRIT J HAEMATOL , 91 (4) 834 - 837.

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Abstract

Plasma NOx concentrations were raised in 22 acute painful crises in SCD. We have measured blood concentrations of nitric oxide metabolites (NOx) in sickle-cell disease (SCD), and shown that they are increased compared with healthy controls (P=0.002), and haemoglobin E/beta-thalassaemic controls (P=0.05), Concentrations in steady-state: SCD were also higher than in healthy controls (P=0.04) but not significantly different from the concentrations at the beginning of painful crises (P=0.34). Importantly. in 12 regularly exchanged sicklers, the mean pre-transfusion NOx concentration did not differ significantly from the control population (P=0.52), suggesting that the changes in NO metabolism can be reversed, It is unlikely that the increased concentrations of NOx in SCD result from anaemia or haemolysis as the untransfused haemoglobin E/beta-thalassaemics did not show increased levels.

Type: Article
Title: THE METABOLITES OF NITRIC-OXIDE IN SICKLE-CELL DISEASE
Keywords: SICKLE-CELL DISEASE, NITRIC OXIDE, EXCHANGE TRANSFUSION, BLOOD NITRATE, HEMOGLOBIN E/BETA-THALASSEMIA, ARGININE, NO
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/91709
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