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Neutrophil CD11b expression in patients with venous disease

Shields, DA; Saharay, M; TimothyAntoine, C; Porter, JB; Scurr, JH; Smith, PDC; (1996) Neutrophil CD11b expression in patients with venous disease. PHLEBOLOGY , 11 (2) 55 - 59.

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Abstract

Objective: To determine whether neutrophil CD11b, a marker of neutrophil adhesion, differs in patients with varying degrees of severity of venous disease, and to compare the values obtained with those of age-matched normal control subjects.Design: Prospective study, measuring white cell count and neutrophil CD11b expression in whole blood using a fluorescent-labelled monoclonal antibody in a flow cytometer.Setting: The Middlesex Hospital Vascular Laboratory, a referral centre for the investigation of venous disease.Patients: Ten patients with uncomplicated varicose veins, 10 patients with skin changes of lipodermatosclerosis (LDS), and 20 age-matched control subjects with no history or clinical finding of venous disease.Results: Higher levels of CD11b were found in patients with uncomplicated varicose veins compared with their controls (median 4.6 cf. 1.43 for normal controls, p = 0.005, Mann-Whitney U-test, difference between medians 2.7, 95% confidence interval 1 to 4.6), and lower levels in patients with LDS (median 1.22 cf. 1.53 for normal controls, p = 0.028, Mann-Whitney U-test, difference between medians 0.45, 95% confidence interval 0.02 to 1.3). There was no difference in the white cell or neutrophil count between the patient and control groups.Conclusions: This study demonstrates increased neutrophil surface CD11b expression in patients with uncomplicated varicose veins, but decreased levels in patients with LDS. This might be due to up-regulation of CD11b in some neutrophils with subsequent adhesion, so that only those with low expression remained in the peripheral circulation. Alternatively, this might represent either down-regulation or chronic exhaustion of neutrophil CD11b in these patients.

Type: Article
Title: Neutrophil CD11b expression in patients with venous disease
Keywords: CD11b, neutrophil adhesion, venous disease, venous hypertension, venous ulceration - aetiology, ANTIBODY IMMUNOSORBENT-ASSAY, ALPHA-2-PLASMIN INHIBITOR, PLASMA, ELASTASE, ACCUMULATION, HYPERTENSION, COMPLEXES, ADHESION, SKIN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/91700
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