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Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study

Barber, NJ; Zhang, X; Zhu, G; Pramanik, R; Barber, JA; Martin, FL; Morris, JDH; (2006) Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study. PROSTATE CANCER P D , 9 (4) 407 - 413. 10.1038/sj.pcan.4500895.

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Abstract

Interest in lycopene has focused primarily on its use in the chemoprevention of prostate cancer (CaP); there are few clinical trials involving men with established disease. In addition, most data examining its mechanism of action have been obtained from experiments using immortal cell lines. We report the inhibitory effect(s) of lycopene in primary prostate epithelial cell (PEC) cultures, and the results of a pilot phase II clinical study investigating whole-tomato lycopene supplementation on the behavior of established CaP, demonstrating a significant and maintained effect on prostate-specific antigen velocity over 1 year. These data reinforce the justification for a large, randomized, placebo-controlled study.

Type: Article
Title: Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study
DOI: 10.1038/sj.pcan.4500895
Keywords: prostate cancer, lycopene, diet, GAP JUNCTIONAL COMMUNICATION, CANCER PATIENTS, CAROTENOIDS, RISK, PROLIFERATION, INTERVENTION, CARCINOMA, RETINOL, PLASMA, GROWTH
UCL classification: UCL > School of BEAMS > Faculty of Maths and Physical Sciences
UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Statistical Science
URI: http://discovery.ucl.ac.uk/id/eprint/91527
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