Kooyman, DL and Byrne, GW and McClellan, S and Nielsen, D and Tone, M and Waldmann, H and Coffman, TM and McCurry, KR and Platt, JL and Logan, JS (1995) In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium. Science , 269 (5220) 89 - 92.
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Many proteins are associated with the outer layer of the cell membrane through a posttranslationally added glycosyl phosphatidylinositol (GPI) anchor. The functional significance of this type of protein linkage is unclear, although it results in increased lateral mobility, sorting to the apical surface of the cell, reinsertion into cell membranes, and possibly cell signaling. Here evidence is presented that GPI-linked proteins can undergo intermembrane transfer in vivo. GPI-linked proteins expressed on the surface of transgenic mouse red blood cells were transferred in a functional form to endothelial cells in vivo. This feature of GPI linkage may be potentially useful for the delivery of therapeutic proteins to vascular endothelium.
|Title:||In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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