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Gene transfer to somatic tissues using retroviral vectors.

Moullier, P; Marechal, V; Ferry, N; Naffakh, N; Heard, JM; Danos, O; (1991) Gene transfer to somatic tissues using retroviral vectors. Nouv Rev Fr Hematol , 33 (6) pp. 493-495.

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Abstract

Retroviral vectors have successfully been used for stable gene transfer in a number of in vivo situation. Before this approach can reallistically be applied in the treatment of human genetic diseases, the correction of pathological symptoms have to be documented in an animal model. In this perspective, we have chosen to use a strain of mice carrying the gusmps mutation, where homozygotes are deficient for beta-glucuronidase and develop a mucopolysaccharidosis. Two methods which result in the stable introduction of the human beta-glucuronidase cDNA into skin fibroblasts or hematopoietic stem cells are presented. A third method, whereby genes can be stably transferred to the liver is also discussed.

Type: Article
Title: Gene transfer to somatic tissues using retroviral vectors.
Location: Germany
Keywords: Animals, Disease Models, Animal, Fibroblasts, Genetic Therapy, Genetic Vectors, Hematopoietic System, Liver, Mucopolysaccharidosis IV, Retroviridae, Skin, Skin Physiological Phenomena, Transfection
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/90947
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