Rahamim, JS; Murphy, GJ; Awan, Y; Junemann-Ramirez, M; (2003) The effect of age on the outcome of surgical treatment for carcinoma of the oesophagus and gastric cardia. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY , 23 (5) 805 - 810. 10.1016/S1010-7940(03)00034-4.
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Objective: The aim of this study was to examine the effect of age on the outcome of surgical treatment for carcinoma of the oesophagus and gastric cardia. Methods: From 1979 to 1999, 596 patients underwent gastro-oesophagectomy with two-field lymph node clearance for cancer under the care of a single surgeon. The clinicopathologic characteristics and survival of patients aged between 45 and 63 years (n = 198, Group 1), 63 and 71 years (n = 199, Group 2) and 71 and 89 years (n = 199, Group 3) were compared. Results: Thirty-day mortality for the first 300 patients (1979-1993) in this consecutive series was 5, 8 and 18% for Groups 1, 2 and 3, respectively, and 6, 6 and 6% for Groups 1, 2 and 3, respectively, in the second consecutive 296 patients (1993-1999, P = 0.006, chi(2)). Tumours were poorly differentiated in 55.7, 59.1 and 53.4% of patients in Groups 1, 2 and 3, respectively, for 1979-1993 and 64.7, 53.2 and 40.2% of tumours in Groups 1, 2 and 3, respectively, for 1993-1999 (P = 0.02, chi(2)). Adjuvant therapy was significantly more common in younger patients (P = 0.006, chi(2)). Five-year survival in the first period was 22, 15 and 11% for Groups 1, 2 and 3, respectively, (P = 0.02 log-rank) and 18, 16 and 14% for Groups 1, 2 and 3 in the second period (P = NS, log-rank). Conclusions: Elderly patients now have equivalent short and long-term outcomes compared to younger patients following gastro-oesophagectomy. Five-year survival, even in younger patients receiving adjuvant therapy remains poor, however, at approximately 20%. New therapeutic modalities are required to improve long-term survival following surgical treatment of gastro-oesophageal carcinoma. (C) 2003 Elsevier Science B.V. All rights reserved.
|Title:||The effect of age on the outcome of surgical treatment for carcinoma of the oesophagus and gastric cardia|
|Keywords:||gastro-oesophagectomy, oesophageal carcinoma, SQUAMOUS-CELL CARCINOMA, LYMPH-NODE DISSECTION, ESOPHAGEAL-CARCINOMA, ELDERLY PATIENTS, YOUNG-PATIENTS, CANCER, ADENOCARCINOMA, RESECTION|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)|
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