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Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.

Schwartz, O; Dautry-Varsat, A; Goud, B; Maréchal, V; Subtil, A; Heard, JM; Danos, O; (1995) Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes. J Virol , 69 (1) pp. 528-533.

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Abstract

We have studied the fate of CD4 in CEM T cells expressing a human immunodeficiency virus type 1 HIV-1 Nef protein. Nef triggered a rapid endocytosis and a degradation of CD4, while most of the p56lck was upheld at the cell membrane. In the presence of Nef, CD4 accumulated in acidic intracellular vesicles that were not stained by antibodies against rab6, a marker of the Golgi apparatus complex. Detection of transferrin in CD4-containing vesicles showed that CD4 was trapped in early endosomes, without significant accumulation of CD4 in late endocytic compartments. Internalization pathways taken by CD4 in Nef+ cells may therefore be different from those observed after treatment with phorbol esters.

Type: Article
Title: Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
Location: United States
Keywords: CD4 Antigens, Cell Line, Endocytosis, Endosomes, Gene Products, nef, HIV-1, Humans, nef Gene Products, Human Immunodeficiency Virus
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/90920
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