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The role of antibodies in dysfunction of pig-to-baboon pulmonary transplants.

Lau, CL; Daggett, WC; Yeatman, MF; Chai, P; Lin, SS; Lodge, AJ; Chen, EP; ... Davis, RD; + view all (2000) The role of antibodies in dysfunction of pig-to-baboon pulmonary transplants. J Thorac Cardiovasc Surg , 120 (1) pp. 29-38. 10.1067/mtc.2000.106841.

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OBJECTIVE: Pulmonary transplantation has become the preferred treatment for end-stage lung disease, but application of the procedure is limited because of a paucity of donors. One way to solve donor limitations is to use animal organs as a donor source or xenotransplantation. The current barrier to pulmonary xenotransplantation is the rapid failure of the pulmonary xenograft. Although antibodies are known to play a role in heart and kidney xenograft rejection, their involvement in lung dysfunction is less defined. This project was designed to define the role of antibodies in pulmonary graft rejection in a pig-to-baboon model. METHODS: Orthotopic transgenic swine left lung transplants were performed in baboons depleted of antibodies by one of three techniques before transplantation: (1) ex vivo swine kidney perfusion, (2) total immunoglobulin-depleting column perfusion, and (3) ex vivo swine lung perfusion. Results were compared with those of transgenic swine lung transplants in unmodified baboons. RESULTS: All three techniques of antibody removal resulted in depletion of xenoreactive antibodies. Only pretransplantation lung perfusion improved pulmonary xenograft function compared with lung transplantation in unmodified baboons. CONCLUSIONS: The pathogenesis of pulmonary injury in a swine-to-primate transplant model is different from that in renal and cardiac xenografts. Depletion of antibodies alone does not have a beneficial effect and may actually be detrimental.

Type: Article
Title: The role of antibodies in dysfunction of pig-to-baboon pulmonary transplants.
Location: United States
DOI: 10.1067/mtc.2000.106841
Keywords: Animals, Antibodies, Graft Rejection, Lung Transplantation, Papio, Swine, Transplantation Immunology, Transplantation, Heterologous
URI: http://discovery.ucl.ac.uk/id/eprint/90883
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