McGregor, CG and Teotia, SS and Byrne, GW and Michaels, MG and Risdahl, JM and Schirmer, JM and Tazelaar, HD and Walker, RC and Logan, JS (2004) Cardiac xenotransplantation: progress toward the clinic. Transplantation , 78 (11) 1569 - 1575.
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Animal organs could satisfy the demand for solid organ transplants, which currently exceeds the limited human donor supply. Hyperacute rejection, the initial immune barrier to successful xenotransplantation, has been overcome with pig donors transgenic for human complement regulatory proteins. Delayed xenograft rejection, thought to be mediated by anti-pig antibodies predominantly to Gal antigens, is currently regarded as the major barrier to successful xenotransplantation. A median graft survival of 90 days in the life-supporting position is considered a reasonable initial standard for consideration of entry to the clinic.
|Title:||Cardiac xenotransplantation: progress toward the clinic.|
|Keywords:||Animals, Cytomegalovirus Infections, Disaccharides, Graft Survival, Heart Transplantation, Lymphoproliferative Disorders, Myocardium, Papio, Swine, Transplantation, Heterologous|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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