UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Skin graft survival in genetically identical cloned pigs.

Martin, MJ; Yin, D; Adams, C; Houtz, J; Shen, J; Chong, AS; Sharma, A; ... Logan, JS; + view all (2003) Skin graft survival in genetically identical cloned pigs. Cloning Stem Cells , 5 (2) pp. 117-121. 10.1089/153623003322234713.

Full text not available from this repository.


Nuclear transfer technology allows for the reprogramming of somatic cells, and the production of embryonic stem cells and animals that are genetically identical in terms of nuclear DNA to the parental somatic cell. It is assumed that these products of nuclear transfer technology will be immunologically compatible to each other in spite of the fact that there are data that show differences in the expression patterns and phenotypes between animals produced by nuclear transfer. We have produced a series of cloned pigs from embryonic fibroblasts. Microsatellite analysis was used to confirm that the clones were genetically identical. Skin transplants were performed to assess immunological reactivity. Skin transplants between genetically identical cloned pigs were accepted, whereas third party grafts were rejected. Histological analysis of the grafts showed edema and mononuclear cell infiltrates in the recipient's skin in rejected grafts and not in grafts that were accepted. Our data supports the notion that genetically identical cloned pigs are immunologically compatible.

Type: Article
Title: Skin graft survival in genetically identical cloned pigs.
Location: United States
DOI: 10.1089/153623003322234713
Keywords: Animals, Cell Line, Cloning, Organism, Embryo, Mammalian, Fibroblasts, Graft Survival, Nuclear Transfer Techniques, Skin Transplantation, Swine
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/90872
Downloads since deposit
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item