Byrne, GW and Davies, WR and Oi, K and Rao, VP and Teotia, SS and Ricci, D and Tazelaar, HD and Walker, RC and Logan, JS and McGregor, CG (2006) Increased immunosuppression, not anticoagulation, extends cardiac xenograft survival. Transplantation , 82 (12) 1787 - 1791. 10.1097/01.tp.0000251387.40499.0f.
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Cardiac xenograft function is lost due to delayed xenograft rejection (DXR) characterized by microvascular thrombosis and myocardial necrosis. The cause of DXR is unknown but may result from thrombosis induced by antibody-mediated activation of endothelial cells and/or by incompatibilities in thromboregulatory interactions.
|Title:||Increased immunosuppression, not anticoagulation, extends cardiac xenograft survival.|
|Keywords:||Animals, Anticoagulants, Blood Coagulation, Enoxaparin, Graft Rejection, Graft Survival, Heart Transplantation, Immunosuppression, Immunosuppressive Agents, Papio, Splenectomy, Swine, Thrombosis, Transplantation, Heterologous|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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