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Increased immunosuppression, not anticoagulation, extends cardiac xenograft survival.

Byrne, GW; Davies, WR; Oi, K; Rao, VP; Teotia, SS; Ricci, D; Tazelaar, HD; (2006) Increased immunosuppression, not anticoagulation, extends cardiac xenograft survival. Transplantation , 82 (12) 1787 - 1791. 10.1097/01.tp.0000251387.40499.0f.

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Abstract

Cardiac xenograft function is lost due to delayed xenograft rejection (DXR) characterized by microvascular thrombosis and myocardial necrosis. The cause of DXR is unknown but may result from thrombosis induced by antibody-mediated activation of endothelial cells and/or by incompatibilities in thromboregulatory interactions.

Type: Article
Title: Increased immunosuppression, not anticoagulation, extends cardiac xenograft survival.
Location: United States
DOI: 10.1097/01.tp.0000251387.40499.0f
Language: English
Keywords: Animals, Anticoagulants, Blood Coagulation, Enoxaparin, Graft Rejection, Graft Survival, Heart Transplantation, Immunosuppression, Immunosuppressive Agents, Papio, Splenectomy, Swine, Thrombosis, Transplantation, Heterologous
UCL classification: UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/90858
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