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Transcranial magnetic stimulation as a method for investigating the plasticity of the brain in Parkinson's Disease and dystonia

Rothwell, J; (2007) Transcranial magnetic stimulation as a method for investigating the plasticity of the brain in Parkinson's Disease and dystonia. PARKINSONISM & RELATED DISORDERS , 13 S417 - S420.

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Abstract

It is now possible to probe the plasticity of some neural circuits in the human motor cortex using transcranial magnetic stimulation (TMS). This article illustrates how changes in the plasticity of these circuits is linked to the expression of dyskinesias in Parkinson's disease, and may even underlie the tendency of some individuals to develop focal dystonia. Indeed, gradual normalisation of this excessive plasticity occurs after initiating deep brain Stimulation of the internal globus pallidus in patients with generalised dystonia. It may therefore relate to the slow onset of clinical improvement that occurs over the first 6 weeks or so of treatment. (c) 2007 Elsevier B.V. All rights reserved.

Type: Article
Title: Transcranial magnetic stimulation as a method for investigating the plasticity of the brain in Parkinson's Disease and dystonia
Location: Amsterdam, NETHERLANDS
Keywords: transcranial magnetic stimulation, synaptic plasticity, Parkinson's disease, dyskinesias, dystonia, deep brain stimulation, PAIRED ASSOCIATIVE STIMULATION, MOTOR CORTEX, CORTICAL PLASTICITY, CARRIERS, DYSKINESIAS, MUTATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/90730
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