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Targeting cell death.

Hausenloy, DJ; Scorrano, L; (2007) Targeting cell death. Clin Pharmacol Ther , 82 (4) pp. 370-373. 10.1038/sj.clpt.6100352.

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Abstract

Functional consequences of myocardial or cerebral infarction are the result of excessive cell death. It is patent that preventing cell death is the therapeutic goal in any ischemia-reperfusion setting. Mitochondria amplify apoptotic cascades and have emerged as crucial organelles in ischemia-reperfusion. Changes in mitochondrial inner membrane permeability and in the morphology of the organelle are regulated, perhaps interconnected processes that are starting to emerge as novel therapeutic targets for reducing cell death induced by ischemia-reperfusion.

Type: Article
Title: Targeting cell death.
Location: United States
DOI: 10.1038/sj.clpt.6100352
Keywords: Animals, Apoptosis, Cardiovascular Agents, Humans, Mitochondria, Heart, Mitochondrial Membrane Transport Proteins, Mitochondrial Membranes, Myocardial Reperfusion Injury, Myocytes, Cardiac, Permeability
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: http://discovery.ucl.ac.uk/id/eprint/90564
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