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Realizing the clinical potential of ischemic preconditioning and postconditioning

Yellon, DM; Hausenloy, DJ; (2005) Realizing the clinical potential of ischemic preconditioning and postconditioning. NAT CLIN PRACT CARD , 2 (11) 568 - 575. 10.1038/ncpcardio0346.

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Abstract

After an acute myocardial infarction (AMI), early reperfusion by thrombolysis or primary percutaneous coronary intervention remains the mist-effective strategy for limiting the size of an evolving infarct. The mortality from AMI, however remains significant, dsue partly to the lethal reperfusion injury that occurs on reperfusion the ischemic myocardium. Novel cardioprotective strategies are required to target this forum of injury. In ischemic preconditioning transient, nonlethal episodes of myocardial ischemia and reperfusion before the index ischemic preconditioning has not been realized in clinical practice because it necessitates an intervention applied before the onset of AMI, which is difficult to predict. A more-amenable approach to cardioprotection is to intervene at the onset of reperfusion, the timing of which is under the control of the operator. In this regard, ischemic postconditioning, in which transient episodes of myocardial ischemia and reperfusion administered at the onset of reperfusion reduce infarct sixe, constitutes one such intervention. Interestingly, studies suggest that ischemic preconditioning and postconditioning, activate the same signaling pathway at the time of myocardial reperfusion might allow one to harness the cardioprotective potential of ischemic preconditioning and postconditioning. in this review, we discuss the potential application of ischemic preconditioning and postconditioning in the clinical arena of myocardial ischemia and reperfusion, and examine the common signaling pathways by which this might be achieved.

Type: Article
Title: Realizing the clinical potential of ischemic preconditioning and postconditioning
DOI: 10.1038/ncpcardio0346
Keywords: ischemic postconditioning, ischemic preconditioning, kinases, mitochondrial permeability transition pore, reperfusion injury, MITOCHONDRIAL PERMEABILITY TRANSITION, ACUTE MYOCARDIAL-INFARCTION, AMERICAN-HEART-ASSOCIATION, GLUCAGON-LIKE PEPTIDE-1, REPERFUSION INJURY, ISCHEMIA/REPERFUSION INJURY, RECEPTOR ACTIVATION, BRIEF HYPOXIA, PROTECTION, THERAPY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: http://discovery.ucl.ac.uk/id/eprint/90558
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