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Non-invasive radioiodine imaging for accurate quantitation of NIS reporter gene expression in transplanted hearts.

Ricci, D; Mennander, AA; Pham, LD; Rao, VP; Miyagi, N; Byrne, GW; Russell, SJ; (2008) Non-invasive radioiodine imaging for accurate quantitation of NIS reporter gene expression in transplanted hearts. Eur J Cardiothorac Surg , 33 (1) 32 - 39. 10.1016/j.ejcts.2007.09.033.

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Abstract

We studied the concordance of transgene expression in the transplanted heart using bicistronic adenoviral vector coding for a transgene of interest (human carcinoembryonic antigen: hCEA - beta human chorionic gonadotropin: betahCG) and for a marker imaging transgene (human sodium iodide symporter: hNIS).

Type: Article
Title: Non-invasive radioiodine imaging for accurate quantitation of NIS reporter gene expression in transplanted hearts.
Location: Germany
DOI: 10.1016/j.ejcts.2007.09.033
Language: English
Keywords: Animals, Carcinoembryonic Antigen, Chorionic Gonadotropin, Gene Expression, Genes, Reporter, Heart Transplantation, Iodine Radioisotopes, Male, Rats, Rats, Inbred Lew, Symporters, Tomography, Emission-Computed, Single-Photon, Treatment Outcome
UCL classification: UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/90546
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