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Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantation.

Byrne, GW; Stalboerger, PG; Davila, E; Heppelmann, CJ; Gazi, MH; McGregor, HC; LaBreche, PT; (2008) Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantation. Xenotransplantation , 15 (4) 268 - 276. 10.1111/j.1399-3089.2008.00480.x.

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Abstract

Experience with non-antigenic galactose alpha1,3 galactose (alphaGal) polymers and development of alphaGal deficient pigs has reduced or eliminated the significance of this antigen in xenograft rejection. Despite these advances, delayed xenograft rejection (DXR) continues to occur most likely due to antibody responses to non-Gal endothelial cell (EC) antigens.

Type: Article
Title: Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantation.
Location: Denmark
DOI: 10.1111/j.1399-3089.2008.00480.x
Language: English
Keywords: Animals, Animals, Genetically Modified, Antibodies, Heterophile, Antibody Specificity, Disaccharides, Graft Rejection, Heart Transplantation, Humans, Papio anubis, Proteomics, Swine, Transplantation, Heterologous
UCL classification: UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/90515
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