Byrne, GW and Stalboerger, PG and Davila, E and Heppelmann, CJ and Gazi, MH and McGregor, HC and LaBreche, PT and Davies, WR and Rao, VP and Oi, K and Tazelaar, HD and Logan, JS and McGregor, CG (2008) Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantation. Xenotransplantation , 15 (4) 268 - 276. 10.1111/j.1399-3089.2008.00480.x.
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Experience with non-antigenic galactose alpha1,3 galactose (alphaGal) polymers and development of alphaGal deficient pigs has reduced or eliminated the significance of this antigen in xenograft rejection. Despite these advances, delayed xenograft rejection (DXR) continues to occur most likely due to antibody responses to non-Gal endothelial cell (EC) antigens.
|Title:||Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantation.|
|Additional information:||PMCID: PMC2586876|
|Keywords:||Animals, Animals, Genetically Modified, Antibodies, Heterophile, Antibody Specificity, Disaccharides, Graft Rejection, Heart Transplantation, Humans, Papio anubis, Proteomics, Swine, Transplantation, Heterologous|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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