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HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection

Khakoo, SI; Thio, CL; Martin, MP; Brooks, CR; Gao, XJ; Astemborski, J; Cheng, J; ... Carrington, M; + view all (2004) HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. SCIENCE , 305 (5685) 872 - 874.

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Abstract

Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low infectious doses of HCV but not in those with high-dose exposure, in whom the innate immune response is likely overwhelmed. The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.

Type: Article
Title: HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
Keywords: RECOGNITION, CYTOMEGALOVIRUS, ACTIVATION, ARTHRITIS, DIVERSITY, LOCUS, BLOOD
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: http://discovery.ucl.ac.uk/id/eprint/9036
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