Koak, Y; Winslet, M; (2002) Changing role of in vivo models in columnar-lined lower esophagus. DIS ESOPHAGUS , 15 (4) 271 - 277.
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Columnar-lined lower esophagus (CLE) or Barrett's esophagus (BE) is caused by chronic reflux of the gastrointestinal tract and can progress to invasive adenocarcinoma. However, the pathophysiology, cell of origin, and management of this condition is incompletely understood. This review evaluates the role of in vivo models in resolving these debates. A search was performed on the Ovid and Pub Medline for 1964-2001 and Cochrane Collaboration. The keywords used were adenocarcinoma, animal model, Barrett's esophagus, columnar-lined esophagus, eosophageal neoplasms, and esophageal carcinogenesis. All relevant papers were scrutinized and an attempt at tabulation was made. In vivo models have been used at several stages of debate on the pathophysiology of BE. They provide conclusive evidence for its acquired nature secondary to duodenogastro-esophageal reflux. The cell of origin of experimental BE may arise from adjacent columnar epithelium, basal layer multipotent cells, or esophageal glands. Experimental work on BE is lacking in assessing therapeutic modalities.
|Title:||Changing role of in vivo models in columnar-lined lower esophagus|
|Keywords:||ZINC-DEFICIENT RATS, MUCOSAL BARRIER DISRUPTION, EPIDERMAL-GROWTH-FACTOR, N-NITROSOMETHYLBENZYLAMINE, BARRETTS-ESOPHAGUS, CELL-PROLIFERATION, REFLUX ESOPHAGITIS, DUODENOESOPHAGEAL REFLUX, GASTRODUODENAL CONTENTS, ALKALINE ESOPHAGITIS|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)|
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