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Radioimmunodetection: technical problems and methods of improvement

Sergides, IG; Austin, RCT; Winslet, MC; (1999) Radioimmunodetection: technical problems and methods of improvement. EUR J SURG ONCOL , 25 (5) 529 - 539.

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Abstract

Radioimmunodetection (RAID) is a technique which uses radiolabelled antibodies to visualize tumours, taking advantage of antigens preferentially expressed by malignant tissue. Gamma radiation emitted by radioisotopes can be detected using an external gamma camera (RAID), or intraoperatively with a hand-held Geiger counter (radioimmunoguided surgery, RIGS). RAID has significant inherent problems, Many have been overcome as a result of nearly 50 years of research, and others still remain as obstacles precluding the routine use of the technique. This article summarizes the technical limitations of RAID and outlines the relative successes of the methods evolved to overcome them.

Type: Article
Title: Radioimmunodetection: technical problems and methods of improvement
Keywords: adult, radioimmunodetection, technical, RADIOLABELED MONOCLONAL-ANTIBODIES, NUCLEAR-DNA CONTENT, CARCINOEMBRYONIC ANTIGEN, COLORECTAL-CANCER, TUMOR-LOCALIZATION, COLON-CARCINOMA, F(AB')2 FRAGMENTS, XENOGRAFT MODEL, LYMPHOCYTES-B, HIGH-AFFINITY
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/90211
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