WINSLET, MC; POXON, V; ALLAN, A; KEIGHLEY, M; (1993) THE INFLUENCE OF ILEAL POUCH-ANAL ANASTOMOSIS FOR ULCERATIVE-COLITIS ON ILEAL GLYCOPROTEIN-SYNTHESIS. SCAND J GASTROENTERO , 28 (6) 500 - 502.
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Restorative proctocolectomy and ileal pouch-anal anastomosis are frequently associated with the onset of low-grade inflammation, colonic metaplasia, and pouchitis. The influence of intestinal adaptation and inflammatory activity on ileal glycoprotein synthesis (GS) has been assessed. Ileal GS activity in controls (n = 13, 28.9 +/- 3.6) was similar to that of patients with ulcerative colitis (n = 18, 26.4 +/- 3.6) irrespective of the presence of backwash ileitis (n = 6, 22.0 +/- 4.0). Ileoanal pouch construction was not associated with a significant change in ileal GS activity regardless of the presence of low-grade inflammation (n = 19, 25.9 +/- 2.2), frank pouchitis (n = 5, 24.4 +/- 4.6), or transformation to a colonic type of mucosa (n = 6, 25.4 +/- 5.2). The transformation of ileal mucosa from an absorptive to a storage function is associated with characteristic morphologic and inflammatory changes but does not produce a protective response mediated by increased GS.
|Title:||THE INFLUENCE OF ILEAL POUCH-ANAL ANASTOMOSIS FOR ULCERATIVE-COLITIS ON ILEAL GLYCOPROTEIN-SYNTHESIS|
|Keywords:||CROHNS DISEASE, ILEAL POUCH ANAL ANASTOMOSIS, RESTORATIVE PROCTOCOLECTOMY, ULCERATIVE COLITIS, DISEASE|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)|
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