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Combined reconstruction of fluorescent and optical parameters using time-resolved data

Soloviev, VY; D'Andrea, C; Valentini, G; Cubeddu, R; Arridge, SR; (2009) Combined reconstruction of fluorescent and optical parameters using time-resolved data. APPL OPTICS , 48 (1) 28 - 36.

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Abstract

We present an algorithm for simultaneous reconstruction of optical parameters, quantum yield, and life-time in turbid media with embedded fluorescent inclusions. This algorithm is designed in the Fourier domain as an iterative solution of a system of differential equations of the Helmholtz type and does not involve full ill-conditioned matrix computations. The approach is based on allowing the unknown optical parameters, quantum yield, and lifetime to depend on the Fourier spectral parameter. The algorithm was applied to a time-gated experimental data set acquired by imaging a highly scattering cylindrical phantom concealing small fluorescent tubes. Relatively accurate reconstruction demonstrates the potential of the method. (C) 2008 Optical Society of America

Type:Article
Title:Combined reconstruction of fluorescent and optical parameters using time-resolved data
Keywords:TURBID MEDIA, MOLECULAR TOMOGRAPHY, IMAGE-RECONSTRUCTION, LIFETIME TOMOGRAPHY, SCATTERING MEDIA, DATA-ACQUISITION, DOMAIN, SCHEME, ILLUMINATION, PROPAGATION
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Computer Science

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