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CD8(+) cytotoxic lymphocyte responses against cytomegalovirus after liver transplantation: Correlation with time from transplant to receipt of tacrolimus

Hassan-Walker, AF; Cuero, ALV; Mattes, FM; Klenerman, P; Lechner, F; Burroughs, AK; ... Emery, VC; + view all (2001) CD8(+) cytotoxic lymphocyte responses against cytomegalovirus after liver transplantation: Correlation with time from transplant to receipt of tacrolimus. JOURNAL OF INFECTIOUS DISEASES , 183 (6) 835 - 843.

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Abstract

The effects of the immunocompromised state after liver transplantation on the frequency of cytomegalovirus-specific cytotoxic T lymphocytes (CTL) were investigated in 93 patients by using HLA class I tetrameric complexes corresponding to HLA-A*0201, HLA-B*0702, HLA-B*0801, and HLA-B*3501 refolded with peptides from the ppUL83 matrix protein. ppUL83 CTL frequencies were suppressed during the first 6 months after transplantation. Patients with >1 HLA-restricted response detected had high correlation among ppUL83 CD8(+) CTL frequencies restricted by different HLA haplotypes (Spearman's rho = .67; P < .0001). There was an inverse correlation among levels of the calcineurin inhibitor, tacrolimus, and ppUL83 CD8(+) CTL frequencies (r = -.31; P = .005), which is consistent with the presence of a large proportion (70%) of activated (CD38(+)) ppUL83 CD8+ CTL within the population of HLA class I tetramer-positive cells.

Type:Article
Title:CD8(+) cytotoxic lymphocyte responses against cytomegalovirus after liver transplantation: Correlation with time from transplant to receipt of tacrolimus
Location:PORTLAND, OR
Keywords:RENAL-ALLOGRAFT RECIPIENTS, EPSTEIN-BARR-VIRUS, CD4(+) T-CELLS, CMV DISEASE, DIRECT VISUALIZATION, HIGH-FREQUENCY, PROTEIN PP65, RISK-FACTORS, IN-VIVO, INFECTION
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Infection and Immunity (Division of) > Research Department of Infection

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