Lemaigre, FP; Durviaux, SM; Truong, O; Lannoy, VJ; Hsuan, JJ; Rousseau, GG; (1996) Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain. P NATL ACAD SCI USA , 93 (18) 9460 - 9464.
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Tissue-specific transcription is regulated in part by cell type-restricted proteins that bind to defined sequences in target genes, The DNA-binding domain of these proteins is often evolutionarily conserved, On this basis, Liver-enriched transcription factors were classified into five families. We describe here the mammalian prototype of a sixth family, which we therefore call hepatocyte nuclear factor 6 (HNF-6). It activates the promoter of a gene involved in the control of glucose metabolism, HNF-6 contains two different DNA-binding domains, One of these corresponds to a novel type of homeodomain. The other is homologous to the Drosophila cut domain. A similar bipartite sequence is coded by the genome of Caenorhabditis elegans.
|Title:||Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain|
|Keywords:||6-PHOSPHOFRUCTO-2-KINASE FRUCTOSE-2,6-BISPHOSPHATASE, PROTEIN-KINASES, BINDING, DROSOPHILA, PROMOTER, GENE, EXPRESSION, SEQUENCES, LOCUS, SPECIFICITY|
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