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Neuroreceptor subunit genes and the genetic susceptibility to Gilles de la Tourette syndrome

Brett, PM; Curtis, D; Robertson, MM; Gurling, HMD; (1997) Neuroreceptor subunit genes and the genetic susceptibility to Gilles de la Tourette syndrome. BIOL PSYCHIAT , 42 (10) 941 - 947.

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Abstract

Segregation studies have shown that Gilles de la Tourette Syndrome (GTS) is probably transmitted as an autosomal dominant gene disorder and can therefore be studied by classical linkage analysis to identify susceptibility loci. Many neurotransmitter systems have been implicated in the etiology of GTS. Most recently the alpha-1 subunit of the glycine receptor etiologically responsible for hyperekplexia has been hypothesized as the cause of the susceptibility to GTS. Because of this and the high concentration of other neuroreceptor genes at 5q33-35, it was decided to study this region and the associated gene cluster on chromosome 4p12-16 in a large British kindred multiply affected with GTS and chronic motor ties. The genotypes of the microsatellite markers at these loci were determined by polymerase chain reaction, The allele data were analyzed using both parametric and nonparametric methods. Approximate multipoint maps were constructed across the regions of interest using FASTLINK. All of the lod scores produced were negative, showing no evidence of linkage to GTS in the family studied. The multipoint maps showed good exclusion across these regions. The glycine receptor gene responsible for hyperekplexia and the other neuroreceptor genes examined in this paper are not involved in the etiology of GTS in this large pedigree. (C) 1997 Society of Biological Psychiatry.

Type: Article
Title: Neuroreceptor subunit genes and the genetic susceptibility to Gilles de la Tourette syndrome
Keywords: Gilles de la Tourette Syndrome, hyperekplexia, glycine receptor GABA receptors, linkage, AUTOSOMAL-DOMINANT TRANSMISSION, MULTILOCUS LINKAGE ANALYSIS, DOPAMINE-D3 RECEPTOR GENE, RADIATION HYBRID MAP, D2-DOPAMINE RECEPTOR, SEGREGATION ANALYSIS, LONG ARM, LOCALIZATION, INHERITANCE, EXCLUSION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: http://discovery.ucl.ac.uk/id/eprint/89045
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