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The Maudsley Family Study. I: Structural brain changes on magnetic resonance imaging in familial schizophrenia

Sharma, T; du Boulay, G; Lewis, S; Sigmundsson, T; Gurling, H; Murray, R; (1997) The Maudsley Family Study. I: Structural brain changes on magnetic resonance imaging in familial schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry , 21 pp. 1297-1315.

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Abstract

1. The authors investigated the prevalence of qualitatively rated structural brain abnormalities in schizophrenic probands and their first-degree relatives from families multiply affected with schizophrenia. 2. Magnetic resonance imaging was used to evaluate brain morphology in 33 schizophrenic probands, 54 of their non-schizophrenic first-degree relatives (including 11 presumed obligate carriers) and 37 unrelated control subjects. Structural images were examined by a neuroradiologist who was blind to diagnostic and family status. 3. 52% of the schizophrenic subjects were rated as showing abnormalities compared with 27% of presumed obligate carriers, 16% of their non-schizophrenic relatives and 11% of unrelated controls. 4. Brain abnormalities were more frequent in schizophrenic subjects from multiplex families than in their first-degree relatives and controls. Abnormalities were also found in unaffected relatives particularly those who appear to be transmitting the disorder.

Type: Article
Title: The Maudsley Family Study. I: Structural brain changes on magnetic resonance imaging in familial schizophrenia
Additional information: Sharma, T du Boulay, G Lewis, S Sigmundsson, T Gurling, H Murray, R eng Clinical Trial Research Support, Non-U.S. Gov't ENGLAND 1998/02/14 Prog Neuropsychopharmacol Biol Psychiatry. 1997 Nov;21(8):1297-315. 1. The authors investigated the prevalence of qualitatively rated structural brain abnormalities in schizophrenic probands and their first-degree relatives from families multiply affected with schizophrenia. 2. Magnetic resonance imaging was used to evaluate brain morphology in 33 schizophrenic probands, 54 of their non-schizophrenic first-degree relatives (including 11 presumed obligate carriers) and 37 unrelated control subjects. Structural images were examined by a neuroradiologist who was blind to diagnostic and family status. 3. 52% of the schizophrenic subjects were rated as showing abnormalities compared with 27% of presumed obligate carriers, 16% of their non-schizophrenic relatives and 11% of unrelated controls. 4. Brain abnormalities were more frequent in schizophrenic subjects from multiplex families than in their first-degree relatives and controls. Abnormalities were also found in unaffected relatives particularly those who appear to be transmitting the disorder.
Keywords: Adult Brain/*pathology Family Female Heterozygote Humans Magnetic Resonance Imaging Male Middle Aged Pedigree Schizophrenia/*genetics/*pathology
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: http://discovery.ucl.ac.uk/id/eprint/89029
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