Gurling, HM; Reveley, MA; Murray, RM; (1984) Increased cerebral ventricular volume in monozygotic twins discordant for alcoholism. Lancet , 1 (8384) 986 - 988.
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21 pairs of monozygotic twins discordant for alcoholism and heavy drinking were examined by computerised tomography. Brain and ventricular volumes were calculated by the use of a semiautomated method with the rater blind to twinship and drinking history. 11 severely dependent alcoholics had larger ventricular volumes and ventricle/brain ratios than did their normal cotwins. These changes correlated best with the length of time the alcoholic twin had been drinking eight centilitres pure alcohol, equivalent to a bottle of wine, a day.
|Title:||Increased cerebral ventricular volume in monozygotic twins discordant for alcoholism.|
|Keywords:||Alcohol Drinking, Alcoholism, Cerebral Ventriculography, Diseases in Twins, Female, Genetic Variation, Humans, Pregnancy, Time Factors, Tomography, X-Ray Computed, Twins, Twins, Monozygotic|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Mental Health Sciences Unit|
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