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Treatment of pulmonary hypertension in the general adult intensive care unit: a role for oral sildenafil?

Ng, J; Finney, SJ; Shulman, R; Bellingan, GJ; Singer, M; Glynne, PA; (2005) Treatment of pulmonary hypertension in the general adult intensive care unit: a role for oral sildenafil? BRIT J ANAESTH , 94 (6) 774 - 777. 10.1093/bja/aei114.

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Abstract

Use of inhaled nitric oxide for treatment of pulmonary hypertension in adult critical illness is limited by its mode of delivery and high costs, prompting evaluation of alternative therapies. We report the use of oral sildenafil in a patient with severe secondary pulmonary hypertension and right ventricular dysfunction. Following reduction in mean pulmonary artery pressure and pulmonary vascular resistance with inhaled nitric oxide, crossover to sildenafil therapy maintained control of pulmonary hypertension, facilitating discontinuation of respiratory and cardiovascular organ support. The relative pulmonary vascular specificity of oral sildenafil, and its low cost, makes it an attractive therapeutic alternative to inhaled nitric oxide, and warrants further study.

Type:Article
Title:Treatment of pulmonary hypertension in the general adult intensive care unit: a role for oral sildenafil?
DOI:10.1093/bja/aei114
Keywords:complications, pulmonary hypertension, enzymes, phosphodiesterase, inhibition, inhibitors, sildenafil, intensive care, nitric oxide, inhaled, INHALED NITRIC-OXIDE, RESPIRATORY-DISTRESS-SYNDROME, RANDOMIZED CONTROLLED-TRIAL, ACUTE LUNG INJURY, INTRAVENOUS SILDENAFIL, CARDIAC-SURGERY, ARTERIAL-HYPERTENSION, VASODILATOR, THERAPY, COMBINATION
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Clinical Physiology
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

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