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INVIVO EFFECTS OF MACROPHAGE COLONY-STIMULATING FACTOR ON HUMAN MONOCYTE FUNCTION

KHWAJA, A; JOHNSON, B; ADDISON, IE; YONG, K; RUTHVEN, K; ABRAMSON, S; LINCH, DC; (1991) INVIVO EFFECTS OF MACROPHAGE COLONY-STIMULATING FACTOR ON HUMAN MONOCYTE FUNCTION. BRIT J HAEMATOL , 77 (1) 25 - 31.

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Abstract

Macrophage colony-stimulating factor (M-CSF) is reported to enhance a variety of functions of mature monocyte/macrophages in vitro. We have examined the effects of a 2 h intravenous infusion of M-CSF obtained from human urine (hM-CSF) on haematological parameters and selected monocyte functions. There was a rapid, small, but consistent reduction in Hb concentration (means 6.5 +/- 2.3%, P < 0.0005 by paired t test) by the completion of the hM-CSF infusion and small, transient falls in platelet, monocyte and neutrophil counts were noted in the 2 h following the end of the infusion. No effect on monocyte or neutrophil CD11b cellular adhesion molecule expression was detected. Exposure to hM-CSF in vivo did not directly stimulate the monocyte respiratory burst, but increased the percentage of monocytes responding to f-met-leu-phe from 9.8 +/- 2.5 to 16.6 +/- 4.2 (P < 0.01). The number of candida ingested and degraded per 100 monocytes increased from 101 +/- 14 pre-infusion to 160 +/- 22 post-infusion (P < 0.01). There was a rapid increase in the numbers of monocytes entering a skin window membrane from a mean of 226 +/- 71 pre-infusion to 1064 +/- 404 at the end of the infusion, with no effect on neutrophil migration. These data show that the administration of hM-CSF enhances several of the functions of peripheral blood monocytes in vivo, and this may be of benefit in the treatment of selected infections.

Type: Article
Title: INVIVO EFFECTS OF MACROPHAGE COLONY-STIMULATING FACTOR ON HUMAN MONOCYTE FUNCTION
Keywords: BONE-MARROW TRANSPLANTATION, FACTOR CSF-1, NEUTROPHIL MIGRATION, MURINE MACROPHAGES, MOLECULAR-CLONING, CANDIDA-ALBICANS, RECOMBINANT, EXPRESSION, ENHANCEMENT, RECEPTORS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/88631
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