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Recent clinical advances in hypertrophic cardiomyopathy

Elliott, PM; Saumarex, RC; McKenna, WJ; (1995) Recent clinical advances in hypertrophic cardiomyopathy. Heart Failure , 11 (1) pp. 15-25.

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Abstract

Hypertrophic cardiomyopathy is defined by the presence of myocardial hypertrophy in the absence of any other cardiac or systemic cause. The most important complication of the disease is sudden death and the identification and management of high-risk patients remains a major challenge to the clinician. The mechanism of sudden death in the majority of cases is thought to be ventricular rhythm disturbance, but in spite of recent developments in our understanding of the molecular genetics of hypertrophic cardiomyopathy, the factors that create the underlying arrhythmogenic substrate are unclear. This article reviews recent advances in the clinical characterization of the electrical substrate in this disorder and discusses the role of other pathophysiological abnormalities in determining its expression.

Type: Article
Title: Recent clinical advances in hypertrophic cardiomyopathy
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/88191
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