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Metabotropic actions of kainate receptors in the CNS

Rodriguez-Moreno, A; Sihra, TS; (2007) Metabotropic actions of kainate receptors in the CNS. J NEUROCHEM , 103 (6) 2121 - 2135. 10.1111/j.1471-4159.2007.04924.x.

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Abstract

Kainate receptors (KARs), together with NMDA and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPA), are typically described as ionotropic glutamate receptors. Although ionotropic functions for KARs are beginning to be characterized in multiple brain regions, both, in the pre- and post-synaptic compartments of the synapse, there is accumulating evidence that KARs mediate some of their effects without invoking ion-fluxes. Thus, since 1998, when the first metabotropic action of KARs was described in the modulation of GABA release in hippocampal interneurons, there have been increasing reports that some of the functions of KARs involve the participation of intracellular signalling cascades and depend on G protein activation. These surprising observations, attesting metabotropic actions of KARs, akin to those usually attributed to seven transmembrane region G protein-coupled receptors, make the physiological classification and description of glutamate receptors more complex. In the present review, we describe the metabotropic roles of KARs in the CNS and discuss the intriguing properties of this receptor which, structurally shows all the facets of a typical ionotropic receptor, but appears to express a metabotropic remit at some key synapses.

Type: Article
Title: Metabotropic actions of kainate receptors in the CNS
DOI: 10.1111/j.1471-4159.2007.04924.x
Keywords: G protein, GABA, glutamate, kainate receptors, metabotropic, protein kinase A, protein kinase C, MOSSY-FIBER SYNAPSES, CEREBROCORTICAL NERVE-TERMINALS, EXCITATORY SYNAPTIC-TRANSMISSION, LONG-TERM POTENTIATION, D-ASPARTATE RECEPTORS, MEDIATED HETEROSYNAPTIC FACILITATION, PROTEIN-KINASE-A, GLUTAMATE RELEASE, RAT HIPPOCAMPUS, PRESYNAPTIC INHIBITION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/87779
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