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Postnatal changes in response to norepinephrine in the normal and pulmonary hypertensive lung

Schindler, MB; Hislop, AA; Haworth, SG; (2004) Postnatal changes in response to norepinephrine in the normal and pulmonary hypertensive lung. American Journal of Respiratory and Critical Care Medicine , 170 (6) pp. 641-646. 10.1164/rccm.200311-1551OC.

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Abstract

The effect of norepinephrine administration on pulmonary blood flow during the neonatal period is unclear. Therefore, norepinephrine responses were studied in isolated pulmonary arteries, pulmonary veins, and femoral arteries taken from normal pigs from birth to adulthood and from pigs subjected to chronic hypoxia either from birth for 3 days or from 3 to 14 days of age. Normally, the contractile response of pulmonary arteries and veins to norepinephrine decreased after birth (p < 0.01), and alpha(2)-adrenoceptor-mediated relaxation increased in pulmonary arteries and veins and in femoral arteries. Hypoxic exposure from birth prevented the normal postnatal reduction in pulmonary arterial contractile response, nor was there a postnatal increase in pulmonary arterial adrenoceptor- mediated relaxation. When hypoxic exposure followed a period of normal adaptation, the pulmonary arterial contractile response was not enhanced, but relaxation was significantly impaired. The response of pulmonary veins and femoral arteries was not affected by hypoxic exposure. The contractile effect of norepinephrine was 15- to 60-fold greater in isolated systemic arteries than in pulmonary arteries taken from both normal and pulmonary hypertensive piglets at all ages. This suggests that use of norepinephrine to manage systemic hypotension in infants and children will not compromise the pulmonary vasculature

Type: Article
Title: Postnatal changes in response to norepinephrine in the normal and pulmonary hypertensive lung
DOI: 10.1164/rccm.200311-1551OC
Additional information: JournalSEP 15853BJAMER J RESPIR CRIT CARE MED
Keywords: 14, 15, 3, A, AGE, ALL, AND, ARTERIAL, ARTERIES, ARTERY, birth, BLOOD, BLOOD FLOW, BLOOD-FLOW, BOTH, CARE, CHILDREN, EXPOSURE, FLOW, FOR, hypotension, Hypoxia, hypoxic, in infants and children, INCREASE, INFANT, INFANTS, IS, JOURNAL, LUNG, NEONATAL, norepinephrine, OF, P, PULMONARY, PULMONARY ARTERY, Pulmonary Veins, RELAXATION, RESPONSES, SYSTEMIC, THE, Use, Veins
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: http://discovery.ucl.ac.uk/id/eprint/8770
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