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The protein MAP-1B links GABA(c) receptors to the cytoskeleton at retinal synapses

Hanley, JG; Koulen, P; Bedford, F; Gordon-Weeks, PR; Moss, SJ; (1999) The protein MAP-1B links GABA(c) receptors to the cytoskeleton at retinal synapses. NATURE , 397 (6714) 66 - 69.

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Abstract

The ionotropic type-A and type-C receptors for the neurotransmitter gamma-aminobutyric acid (GABA(A) and GABA(C) receptors) are the principal sites of fast synaptic inhibition in the central nervous system(1-3), but it is not known how these receptors are localized at GABA-dependent synapses. GABA(C) receptors, which are composed of rho-subunits(3-6), are expressed almost exclusively in the retina of adult vertebrates, where they are enriched on bipolar cell axon terminals(7-9). Here we show that the microtubule-associated protein 1B (MAP-1B) specifically interacts with the GABA(C) pi subunit but not with GABA(A) receptor subunits. Furthermore, GABA(C) receptors and MAP-1B co-localize at postsynaptic sites on bipolar cell axon terminals. Co-expression of MAP-1B and the pi subunit in COS cells results in a dramatic redistribution of the rho 1 subunit. Our observations suggest a novel mechanism for localizing ionotropic GABA receptors to synaptic sites. This mechanism, which is specific for GABA(C) but not GABA(A) receptors, may allow these receptor subtypes, which have distinct physiological and pharmacological properties, to be differentially localized at inhibitory synapses.

Type: Article
Title: The protein MAP-1B links GABA(c) receptors to the cytoskeleton at retinal synapses
Keywords: A RECEPTORS, XENOPUS OOCYTES, EXPRESSION, SUBUNITS, GEPHYRIN, LOCALIZATION, CLONING, DOMAIN, RHO-1, GENE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/87292
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