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Tracking the source of the hepatitis B virus-specific CD8 T cells during lamivudine treatment.
JOURNAL OF INFECTIOUS DISEASES
679 - 682.
Lamivudine treatment in chronic hepatitis B leads to the reconstitution of virus-specific T cells in the circulation, but it is not clear whether this is the preferential result of T cell efflux from the liver or lymph nodes. To address this question, the frequency and function of liver-, lymph node-, and blood-derived hepatitis B virus (HBV)-specific CD8 T cells were analyzed in patients treated with lamivudine and undergoing liver transplantation. HBV-specific CD8 T cells, identified in portal lymph nodes, were able to expand in vitro after antigen-specific stimulation and displayed a heterogeneous profile of cytokine production. These findings suggest that the peripherally reconstituted HBV-specific CD8 T cells can originate from precursor cells within lymph nodes.
|Title:||Tracking the source of the hepatitis B virus-specific CD8 T cells during lamivudine treatment|
|Open access status:||An open access version is available from UCL Discovery|
|Keywords:||INFECTION, THERAPY, RESPONSES|
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