Malacarne, F and Webster, GJM and Reignat, S and Gotto, J and Behboudi, S and Burroughs, AK and Dusheiko, GM and Williams, R and Bertoletti, A (2003) Tracking the source of the hepatitis B virus-specific CD8 T cells during lamivudine treatment. JOURNAL OF INFECTIOUS DISEASES , 187 (4) 679 - 682.
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Abstract
Lamivudine treatment in chronic hepatitis B leads to the reconstitution of virus-specific T cells in the circulation, but it is not clear whether this is the preferential result of T cell efflux from the liver or lymph nodes. To address this question, the frequency and function of liver-, lymph node-, and blood-derived hepatitis B virus (HBV)-specific CD8 T cells were analyzed in patients treated with lamivudine and undergoing liver transplantation. HBV-specific CD8 T cells, identified in portal lymph nodes, were able to expand in vitro after antigen-specific stimulation and displayed a heterogeneous profile of cytokine production. These findings suggest that the peripherally reconstituted HBV-specific CD8 T cells can originate from precursor cells within lymph nodes.
| Type: | Article |
|---|---|
| Title: | Tracking the source of the hepatitis B virus-specific CD8 T cells during lamivudine treatment |
| Location: | PARIS, FRANCE |
| Open access status: | An open access version is available from UCL Discovery |
| Keywords: | INFECTION, THERAPY, RESPONSES |
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