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Tracking the source of the hepatitis B virus-specific CD8 T cells during lamivudine treatment

Malacarne, F; Webster, GJM; Reignat, S; Gotto, J; Behboudi, S; Burroughs, AK; ... Bertoletti, A; + view all (2003) Tracking the source of the hepatitis B virus-specific CD8 T cells during lamivudine treatment. JOURNAL OF INFECTIOUS DISEASES , 187 (4) 679 - 682. Green open access

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Abstract

Lamivudine treatment in chronic hepatitis B leads to the reconstitution of virus-specific T cells in the circulation, but it is not clear whether this is the preferential result of T cell efflux from the liver or lymph nodes. To address this question, the frequency and function of liver-, lymph node-, and blood-derived hepatitis B virus (HBV)-specific CD8 T cells were analyzed in patients treated with lamivudine and undergoing liver transplantation. HBV-specific CD8 T cells, identified in portal lymph nodes, were able to expand in vitro after antigen-specific stimulation and displayed a heterogeneous profile of cytokine production. These findings suggest that the peripherally reconstituted HBV-specific CD8 T cells can originate from precursor cells within lymph nodes.

Type:Article
Title:Tracking the source of the hepatitis B virus-specific CD8 T cells during lamivudine treatment
Location:PARIS, FRANCE
Open access status:An open access version is available from UCL Discovery
Keywords:INFECTION, THERAPY, RESPONSES

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