Malacarne, F; Webster, GJM; Reignat, S; Gotto, J; Behboudi, S; Burroughs, AK; ... Bertoletti, A; + view all Malacarne, F; Webster, GJM; Reignat, S; Gotto, J; Behboudi, S; Burroughs, AK; Dusheiko, GM; Williams, R; Bertoletti, A; - view fewer (2003) Tracking the source of the hepatitis B virus-specific CD8 T cells during lamivudine treatment. JOURNAL OF INFECTIOUS DISEASES , 187 (4) 679 - 682.
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Lamivudine treatment in chronic hepatitis B leads to the reconstitution of virus-specific T cells in the circulation, but it is not clear whether this is the preferential result of T cell efflux from the liver or lymph nodes. To address this question, the frequency and function of liver-, lymph node-, and blood-derived hepatitis B virus (HBV)-specific CD8 T cells were analyzed in patients treated with lamivudine and undergoing liver transplantation. HBV-specific CD8 T cells, identified in portal lymph nodes, were able to expand in vitro after antigen-specific stimulation and displayed a heterogeneous profile of cytokine production. These findings suggest that the peripherally reconstituted HBV-specific CD8 T cells can originate from precursor cells within lymph nodes.
|Title:||Tracking the source of the hepatitis B virus-specific CD8 T cells during lamivudine treatment|
|Open access status:||An open access version is available from UCL Discovery|
|Keywords:||INFECTION, THERAPY, RESPONSES|
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