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Polarized light imaging of white matter architecture

Larsen, L; Griffin, LD; Grassel, D; Witte, OW; Axer, H; (2007) Polarized light imaging of white matter architecture. MICROSC RES TECHNIQ , 70 (10) 851 - 863. 10.1002/jemt.20488.

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Abstract

Polarized light imaging (PLI) is a method to image fiber orientation in gross histological brain sections based on the birefringent properties of the myelin sheaths. The method uses the transmission of polarized light to quantitatively estimate the fiber orientation and inclination angles at every point of the imaged section. Multiple sections can be assembled into a 3D volume, from which the 3D extent of fiber tracts can be extracted. This article describes the physical principles of PLI and describes two major applications of the method: the imaging of white matter orientation of the rat brain and the generation of fiber orientation maps of the human brain in white and gray matter. The strengths and weaknesses of the method are set out.

Type:Article
Title:Polarized light imaging of white matter architecture
DOI:10.1002/jemt.20488
Keywords:PLI, fiber tracts, polarized light physics, birefringence, crossed polars, postmortem, human, rat, brain, DIFFUSION TENSOR MRI, GROSS HISTOLOGICAL SECTIONS, SCANNING LASER MICROSCOPY, HUMAN BRAIN, WATER DIFFUSION, FIBER ORIENTATION, REFRACTIVE-INDEX, BIREFRINGENCE, VISUALIZATION, LOCALIZATION
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Computer Science

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