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Panton Valentine Leukocidin associated Staphylococcal Disease: A Cross Sectional Study at a London Hospital, England.

Shallcross, LJ; Williams, K; Hopkins, S; Aldridge, RW; Johnson, AM; Hayward, AC; (2009) Panton Valentine Leukocidin associated Staphylococcal Disease: A Cross Sectional Study at a London Hospital, England. Clin Microbiol Infect 10.1111/j.1469-0691.2009.03153.x.

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Abstract

Abstract Recently there has been international concern at the rapid emergence of highly pathogenic strains of Staphylococcus aureus associated with a toxin called Panton Valentine Leukocidin (PVL). In the UK these strains are believed to be rare and mainly severe. We estimate the proportion of staphylococcal infections that are caused by strains containing the PVL genes, and describe risk factors for these infections. Three hundred and ninety consecutive S. aureus clinical isolates, submitted for routine diagnostic purposes were screened for PVL genes. Risk factors for infection were identified from the patient medical record. 12.6% (95% CI 8.3 to 14.4%) of clinical isolates and 22.6% of skin and soft tissue specimens contained the genes for PVL. Methicillin-resistant S. aureus (MRSA) with PVL was rare (1.3% of all isolates) but PVL with Methicillin-sensitive S. aureus (MSSA) was common (11.3% of all specimens). PVL infection was more frequent in males (OR 2.1, 95% CI 1.0 to 4.2), and in young adults aged 20-39 years (OR 3.2, 95% CI 1.2 to 8.4). Over three-quarters of PVL positive S. aureus infections originated in patients based in the community. Community-onset PVL-associated disease is common in the UK and mainly causes skin and soft tissue infections that do not require admission to hospital. Consideration should be given to current infection control strategy, which advocates household contact screening and decolonisation on the assumption that PVL-associated disease is rare.

Type: Article
Title: Panton Valentine Leukocidin associated Staphylococcal Disease: A Cross Sectional Study at a London Hospital, England.
DOI: 10.1111/j.1469-0691.2009.03153.x
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Health Informatics
URI: http://discovery.ucl.ac.uk/id/eprint/86884
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