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LTP and spatial learning - Where to next?

Jeffery, KJ; (1997) LTP and spatial learning - Where to next? HIPPOCAMPUS , 7 (1) 95 - 110.

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Abstract

Hebb suggested, in 1949, that memories could be stored by forming associative connections between neurons if the criterion for increasing the connection strength between them be that they were active simultaneously. Much attention has been devoted towards trying to determine a) if there is a physiological substrate of such a rule, and b) if so, whether the phenomenon participates in real-life memory formation. The discovery of the electrically induced increase in synaptic strength known as long-term potentiation (LTP), in the early 1970s, demonstrated that a neural version of the Hebb rule could be observed under laboratory conditions in the hippocampus, a structure important for some types of learning. However, a quarter of a century later, the evidence linking LTP to learning and memory is still contradictory. The purpose of the present article is to review and assess the types of approach that have been taken in trying to determine whether hippocampal synaptic plasticity participates in memory formation. (C) 1997 Wiley-Liss, Inc.

Type: Article
Title: LTP and spatial learning - Where to next?
Keywords: long-term potentiation, synaptic plasticity, hippocampus, spatial learning, LONG-TERM POTENTIATION, D-ASPARTATE RECEPTOR, PROTEIN-KINASE-C, HIPPOCAMPAL SYNAPTIC TRANSMISSION, EXPLORATION-DEPENDENT MODULATION, RABBIT FOLLOWING STIMULATION, GAMMA-MUTANT MICE, DENTATE GYRUS, NMDA-RECEPTOR, LASTING POTENTIATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
URI: http://discovery.ucl.ac.uk/id/eprint/86654
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