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Different measures of alcohol consumption and risk of coronary heart disease and all-cause mortality: 11-year follow-up of the Whitehall II Cohort Study

Britton, A; Marmot, M; (2004) Different measures of alcohol consumption and risk of coronary heart disease and all-cause mortality: 11-year follow-up of the Whitehall II Cohort Study. Addiction , 99 (1) pp.109-116.

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Abstract

Aims: To investigate the relationship between three measures of alcohol consumption obtained simultaneously in a large cohort and the validated risk of coronary heart disease and all-cause mortality during follow-up. Design: Prospective cohort study with median follow-up of I I years. London-based civil service. Setting: The Whitehall 11 Cohort Study:. Participants A total of 10 308 (33 % female) civil servants aged 35-55 years at baseline (1985-88). Measurements: Self-reported volume of alcohol consumed during past week, frequency of drinking over past year, usual amount consumed per drinking session. Main outcome measures: Coronary heart disease and all-cause mortality until 1999. Findings: A U-shaped relationship was found between volume of alcohol consumed per week and outcome. Compared to those who drank moderately (1080 g alcohol per week), non-drinkers and those drinking more than 248 g per week had approximately a twofold increased risk of mortality. The optimal frequency of drinking was between once or twice a week and daily, after adjustment for average volume consumed per week. Those drinking twice a day or more had an increased risk of mortality (male hazard ratio 2.44 95% Cl 1.31-4.52) compared to those drinking once or twice a week. Drinking only once a month or only on special occasions had a 50% increased risk of mortality. The usual amount consumed per drinking session was not indicative of increased health risk in this cohort. Conclusions: Epidemiological studies should collect information on frequency of drinking in addition to average volume consumed in order to inform sensible drinking advice.

Type: Article
Title: Different measures of alcohol consumption and risk of coronary heart disease and all-cause mortality: 11-year follow-up of the Whitehall II Cohort Study
Additional information: Imported via OAI, 7:29:01 29th Apr 2006
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: http://discovery.ucl.ac.uk/id/eprint/86558
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