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Rapid T-2* mapping using interleaved echo planar imaging

Howseman, AM; Thomas, DL; Pell, GS; Williams, SR; Ordidge, RJ; (1999) Rapid T-2* mapping using interleaved echo planar imaging. MAGN RESON MED , 41 (2) 368 - 374.

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Abstract

Magnetic resonance imaging methods that are sensitive to Tp are widely used in the study of blood oxygenation changes, most notably in functional studies of the brain. In these studies the signal intensity change in T-2*-weighted imaging is related to the coupling of cerebral blood flow and metabolism. Rapid measurement of T-2* itself would offer a valuable method to quantify blood oxygenation changes indirectly and monitor their time course. An interleaved echoplanar imaging (EPI) sequence is presented here that allows maps of T-2* to be generated in a few seconds. The sequence benefits from reduced geometric distortion and an improved point spread function compared with single-shot EPI, A comparison among a set of T-2*-weighted interleaved EPI images, single-shot EPI, and conventional gradient-echo and spin-echo methods is made using a compartmentalized doped water phantom, The interleaved sequence yields accurate T-2* values when compared with reference measurements made using the slower gradient-echo technique. Data acquired from the rat brain at 2.35 T prior to and during an anoxic challenge show, with high temporal resolution, the reduction in T-2* associated with increased levels of deoxyhemoglobin, (C) 1999 Wiley-Liss, Inc.

Type: Article
Title: Rapid T-2* mapping using interleaved echo planar imaging
Keywords: T-2*, interleaved EPI, rapid imaging, brain oxygenation, GRADIENT-ECHO, CAT BRAIN, RESONANCE IMAGE, FOCAL ISCHEMIA, OXYGENATION, MRI, CONTRAST, TIME, EPI, LIMITATIONS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/86139
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