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The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila

del Corral, RD; Aroca, P; Gomez-Skarmeta, JL; Cavodeassi, F; Modolell, J; (1999) The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila. GENE DEV , 13 (13) 1754 - 1761.

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Abstract

The Iroquois complex (Iro-C) homeodomain proteins allow cells at the proximal part of the Drosophila imaginal wing disc to form mesothoracic body wall (notum). Cells lacking these proteins form wing hinge structures instead (tegula and axillary sclerites). Moreover, the mutant cells impose on neighboring wild-type cells more distal developmental fates, like lateral notum or wing hinge. These findings support a tergal phylogenetic origin for the most proximal part of the wing and provide evidence for a novel pattern organizing center at the border between the apposed notum (Iro-C-expressing) and hinge (Iro-C-nonexpressing) cells, This border is not a cell lineage restriction boundary.

Type: Article
Title: The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila
Keywords: Iroquois complex, imaginal wing disc, thorax development, Drosophila, LONG-RANGE ACTION, GENE-EXPRESSION, MORPHOGEN GRADIENT, ADULT DROSOPHILA, LIMB DEVELOPMENT, NERVOUS-SYSTEM, VESTIGIAL GENE, WING DISC, PATTERN, ENCODES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/86101
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