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Ischaemic preconditioning: present position and future directions

Yellon, DM; Baxter, GF; Garcia-Dorado, D; Heusch, G; Sumeray, MS; (1998) Ischaemic preconditioning: present position and future directions. CARDIOVASC RES , 37 (1) 21 - 33.

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Abstract

Preconditioning the myocardium using short episodes of sublethal ischaemia will delay the onset of necrosis during a subsequent lethal ischaemic insult. This powerful protective adaptation of the myocyte has also been observed in other cell types. The potential for clinical application to benefit patients with a variety of pathological conditions has led to an expansion in our knowledge concerning the pathophysiology of ischemia-reperfusion injury and the regulatory mechanisms underlying cellular metabolism. We feel it is timely to assess the current position in this field and provide a critical appraisal to facilitate future research. (C) 1998 Elsevier Science B.V.

Type: Article
Title: Ischaemic preconditioning: present position and future directions
Keywords: ischemic preconditioning, myocardium, myocardial protection, PROTEIN-KINASE-C, GLIBENCLAMIDE-SENSITIVE MECHANISM, ISOLATED RABBIT CARDIOMYOCYTES, REDUCES INFARCT SIZE, RAT CARDIAC MYOCYTES, NO-FLOW ISCHEMIA, MYOCARDIAL PROTECTION, SUBLETHAL ISCHEMIA, POTASSIUM CHANNEL, CONSCIOUS PIGS
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/86004
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