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Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca2+ stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP)

Brailoiu, E; Patel, S; Dun, NJ; (2003) Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca2+ stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP). BIOCHEM J , 373 313 - 318. 10.1042/BJ20030472.

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Abstract

Nicotinic acid-adenine dinucleotide phosphate (NAADP) is a recently described potent intracellular Ca2+ -mobilizing messenger active in a wide range of diverse cell types. In the present study, we, have investigated the interaction of NAADP with other Ca2+ -mobilizing messengers in the release of transmitter at the frog neuromuscular junction. We show, for the first time, that NAADP enhances neurosecretion in response to inositol 1,4,5-trisphosphate (IP3) cADP-ribose (cADPR) and sphingosine 1-phosphate (SlP), but not sphingosylphosphorylcholine. Thapsigargin was without effect on transmitter release in response to NAADP, but blocked the responses to subsequent application of IP3, cADPR and SIP and their potentiation by NAADP. Asynchronous neurotransmitter release may therefore involve functional coupling of endoplasmic reticulum Ca2+ stores with distinct Ca2+ stores targeted by NAADP.

Type: Article
Title: Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca2+ stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP)
DOI: 10.1042/BJ20030472
Keywords: Ca2+ stores, Ca2+ mobilization, endoplasmic reticulum, neurotransmitter release, nicotinic acid-adenine dinucleotide phosphate (NAADP), thapsigargin, CYCLIC ADP-RIBOSE, PANCREATIC BETA-CELLS, MOTOR-NERVE ENDINGS, INOSITOL TRISPHOSPHATE, CA2+-MOBILIZING MESSENGER, RYANODINE RECEPTOR, SPHINGOSINE 1-PHOSPHATE, SKELETAL-MUSCLE, MOBILIZES CA2+, CHANNELS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/85543
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