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NAADP on the up in pancreatic beta cells - a sweet message?

Patel, S; (2003) NAADP on the up in pancreatic beta cells - a sweet message? BIOESSAYS , 25 (5) 430 - 433. 10.1002/bies.10276.

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Abstract

Pancreatic beta cells secrete insulin in response to elevated plasma glucose levels in a Ca2+-dependent fashion. Released insulin may act on the beta cell itself to promote further insulin synthesis and release. Recent studies by Johnson and Misler,(1) Masgrau et al.(2) and Mitchell et al.(3) provide strong evidence (1) for the existence of intracellular Ca2+ stores sensitive to NAADP, a potent Ca2+-mobilizing messenger, and (2) that these Ca2+ stores are involved in both glucose- and insulin-mediated signal transduction. NAADP may therefore play an important role in controling secretion of insulin from pancreatic beta cells. (C) 2003 Wiley Periodicals, Inc.

Type: Article
Title: NAADP on the up in pancreatic beta cells - a sweet message?
DOI: 10.1002/bies.10276
Keywords: ADENINE-DINUCLEOTIDE PHOSPHATE, CYCLIC ADP-RIBOSE, STIMULATED INSULIN-SECRETION, INTRACELLULAR CA2+ STORES, SEA-URCHIN EGGS, CA2+-MOBILIZING MESSENGER, MOBILIZES CA2+, RECEPTOR, CALCIUM, RELEASE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/85542
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