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The effects of D-cycloserine on the consolidation of fear extinction learning, emotional processing and subjective mood in healthy volunteers

McLoughlin, K.; (2010) The effects of D-cycloserine on the consolidation of fear extinction learning, emotional processing and subjective mood in healthy volunteers. Doctoral thesis, UCL (University College London).

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Abstract

This thesis is comprised of three parts. Part 1 is a review of the literature on the efficacy of glutamatergic compounds acting at the N-methyl-D-aspartate receptorglycine site in improving cognitive functioning in schizophrenia. The rationale for using these compounds as cognitive enhancers is presented and then studies for each compound are reviewed in turn. Methodological limitations are raised and recommendations for future research given. Part 2 is an empirical paper describing a healthy volunteer study investigating the effects of D-cycloserine, a partial agonist at the N-methyl-D-aspartate receptor, on fear consolidation and extinction learning, facial emotional processing and subjective mood. Current literature is explored in the introduction, then the research design, methodology and results are presented. Finally, the findings of the study are discussed including clinical implications and areas for future research. Part 3 is a critical appraisal of the research project as a whole with the intention of providing future researchers with valuable insights into this field of study. How the idea for the project developed is outlined, important methodological decisions are explained and strengths and limitations of the research are presented. Clinical implications and directions for future research are discussed and finally personal reflections on the research process are given.

Type:Thesis (Doctoral)
Title:The effects of D-cycloserine on the consolidation of fear extinction learning, emotional processing and subjective mood in healthy volunteers
Language:English
Additional information:Thesis in two volumes: volume 2 is restricted
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Psychology and Language Sciences (Division of)

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