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Lupus anticoagulant testing using plasma spiked with monoclonal antibodies: performance in the UKNEQAS proficiency testing programme

Jennings, I; Mackie, I; Arnout, J; Preston, FE; UK Natl External Quality, ; (2004) Lupus anticoagulant testing using plasma spiked with monoclonal antibodies: performance in the UKNEQAS proficiency testing programme. J THROMB HAEMOST , 2 (12) 2178 - 2184.

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Abstract

We report here results from a United Kingdom National Quality Assessment Scheme (UK NEQAS) exercise in which both plasma spiked with monoclonal antibodies and plasma from a patient known to have lupus anticoagulant (LA) were distributed to 245 hemostasis laboratories with a request for them to test for possible LA using their routine screening procedure. In general, good agreement was seen in the diagnosis of samples spiked with monoclonal antibodies against beta2-glycoprotein 1 (beta2GP1) and prothrombin, the LA-positive patient sample, and a normal pooled plasma; over 87% of centers correctly identified each sample. However, methods employing platelet neutralizing procedures were associated with a higher proportion of false-negative responses with the antiprothrombin-spiked sample, and it is important to recognize that sensitivity and responsiveness of different methods may vary between artificial plasmas and different LA-positive patient plasmas.

Type: Article
Title: Lupus anticoagulant testing using plasma spiked with monoclonal antibodies: performance in the UKNEQAS proficiency testing programme
Keywords: lupus anticoagulant, monoclonal antibodies, quality control, ANTIPHOSPHOLIPID ANTIBODIES, THROMBOSIS, THROMBOPLASTIN, ERYTHEMATOSUS, COAGULATION, GUIDELINES, TIME
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/85292
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