UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Maternal cardiolipin, beta(2)-glycoprotein-I and prothrombin antibody expression in high-risk pregnancies with bilateral abnormal uterine artery Doppler waveforms

Donohoe, S; Geary, M; Kingdom, JCP; Jauniaux, E; Purdy, G; Mackie, IJ; (1999) Maternal cardiolipin, beta(2)-glycoprotein-I and prothrombin antibody expression in high-risk pregnancies with bilateral abnormal uterine artery Doppler waveforms. ULTRASOUND OBST GYN , 13 (5) 317 - 322.

Full text not available from this repository.

Abstract

Objective To compare the frequency of maternal serum antiphospholipid antibodies (to cardiolipin, beta(2)-glycoprotein I and prothrombin) in pregnancies presenting with bilateral abnormal uterine artery Doppler waveforms.Design Retrospective analysis of stored serum.Subjects Cases comprised 47 singleton pregnancies with bilateral abnormal uterine artery Doppler waveforms at 24 weeks of gestation, followed from 20 weeks, and controls were 100 healthy pregnancies with normal uterine artery Doppler waveforms.Methods Ultrasound examination utilized a 5-MHz curvi-linear transabdominal transducer with pulsed and color Doppler facilities. Antiphospholipid antibodies were analyzed by ELISA methodology, and reference ranges were established using the geometric mean +/-2 SD of healthy non-pregnant adults. Human chorionic gonadotropin (hCG) levels were obtained from patient notes.Results Anticardiolipin antibodies were detected in 11 (23%) of the cases (IgG, n = 7; IgM, n = 6) compared with ten (10%) of the controls (p < 0.05). Low titer anticardiolipin IgG (range, 5.5-35.3; median, 6.3 GPL units) and anticardiolipin IgM (range, 3.4-14.7; median, 5.3 MPL units) were detected in cases. Amongst the cases, adverse perinatal outcomes were more common in the presence of raised levels of anticardiolipin antibodies. Anti-beta(2)-glycoprotein I IgG was not detected in any of the cases. Antiprothrombin IgG was not detected, but antiprothrombin IgM occurred in 10.6% of cases compared with 2% of controls.Conclusions Women with persistent bilateral abnormal uterine artery Doppler waveforms in mid-gestation were more likely to express raised levels of anticardiolipin antibodies than healthy controls with normal uteroplacental perfusion. Anticardiolipin antibodies without anti-beta(2)-glycoprotein I binding may be involved in the pathogenesis of uteroplacental ischemia in a proportion of high-risk pregnancies.

Type: Article
Title: Maternal cardiolipin, beta(2)-glycoprotein-I and prothrombin antibody expression in high-risk pregnancies with bilateral abnormal uterine artery Doppler waveforms
Keywords: uterine artery Doppler, antiphospholipid antibody, anticardiolipin, beta(2)-glycoprotein-I, prothrombin, pre-eclampsia, intrauterine growth restriction, VELOCITY WAVE-FORMS, END-DIASTOLIC FLOW, ALPHA-FETOPROTEIN, ANTIPHOSPHOLIPID ANTIBODIES, ANTICARDIOLIPIN ANTIBODIES, UMBILICAL ARTERY, PREECLAMPSIA, PREDICTION, WOMEN, AUTOANTIBODIES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Reproductive Health
URI: http://discovery.ucl.ac.uk/id/eprint/85272
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item