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THE USE OF AN ANTI-BETA(2)-GLYCOPROTEIN-I ASSAY FOR DISCRIMINATION BETWEEN ANTICARDIOLIPIN ANTIBODIES ASSOCIATED WITH INFECTION AND INCREASED RISK OF THROMBOSIS

MCNALLY, T; PURDY, G; MACKIE, IJ; MACHIN, SJ; ISENBERG, DA; (1995) THE USE OF AN ANTI-BETA(2)-GLYCOPROTEIN-I ASSAY FOR DISCRIMINATION BETWEEN ANTICARDIOLIPIN ANTIBODIES ASSOCIATED WITH INFECTION AND INCREASED RISK OF THROMBOSIS. BRIT J HAEMATOL , 91 (2) 471 - 473.

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Abstract

Antiphospholipid antibodies (aPAs), occurring in association with infection, are not generally associated with an increased risk of thrombosis. Anticardiolipin antibodies (aCL) hom patients with infection, unlike those from patients with SLE, do not have the beta(2)GPI cofactor requirements. Antibodies to beta(2)GPI (alpha beta(2)GPI) are more closely associated with a previous history of thrombosis than aCL in patients with SLE. In the present study we have investigated the reactivity of the alpha beta(2)GPI assay for aPAs associated with infection. Serum from 114 patients with infections including syphilis (n=11), tuberculosis (n=63) and Klebsiella (n=42) were assayed for alpha beta(2)GPI and aCL antibodies. The incidence of aCL in serum of patients with tuberculosis, Klebsiella infection and syphilis was 6.0%, 5.0% and 64.0%, respectively, but all patients were negative for alpha beta(2) GPI. These results indicate that the alpha beta(2)GPI assay is negative in patients with transiently positive aCL assays associated with infection.

Type: Article
Title: THE USE OF AN ANTI-BETA(2)-GLYCOPROTEIN-I ASSAY FOR DISCRIMINATION BETWEEN ANTICARDIOLIPIN ANTIBODIES ASSOCIATED WITH INFECTION AND INCREASED RISK OF THROMBOSIS
Keywords: ANTICARDIOLIPIN, ANTI-BETA(2)-GLYCOPROTEIN-I, INFECTION, THROMBOSIS, ANTIPHOSPHOLIPID ANTIBODIES, CARDIOLIPIN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/85255
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