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Increased levels of beta(2) glycoprotein-I antigen and beta(2) glycoprotein-I binding antibodies are associated with a history of thromboembolic complications in patients with SLE and primary antiphospholipid syndrome

McNally, T; Mackie, IJ; Machin, SJ; Isenberg, DA; (1995) Increased levels of beta(2) glycoprotein-I antigen and beta(2) glycoprotein-I binding antibodies are associated with a history of thromboembolic complications in patients with SLE and primary antiphospholipid syndrome. BRIT J RHEUMATOL , 34 (11) 1031 - 1036.

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Abstract

beta(2) Glycoprotein-I (beta(2)GPI), a plasma component with in vitro anticoagulant properties, has been identified as a cofactor for the binding of some antiphospholipid antibodies (aPAs). In order to determine whether beta(2)GPI changes were associated with the thromboembolic complications of aPAs, we measured beta(2)GPI antigen (beta(2)GPI:Ag), beta(2)GPI aPA cofactor activity (beta(2)GPI:Cof) and antibodies to beta(2)GPI (alpha beta(2)GPI) in 44 systemic lupus erythematosus (SLE) patients, of whom 19 had evidence of aPAs (SLE-aPA+) and 17 patients with primary antiphospholipid syndrome (PaPS). beta(2)GPI:Ag levels were significantly increased in SLE-aPA+ patients and PaPS patients compared with SLE-aPA- patients and normal healthy controls. The ratio of beta(2)GPI:Cof/Ag was significantly reduced in SLE-aPA+ patients compared with SLE-aPA- patients, indicating functional modification of beta(2)GPI in SLE-aPA+ patients. Eighty per cent of patients with anticardiolipin (aCL) IgG also had alpha beta(2)GPI, and 13% patients with no detectable aCL IgG had alpha beta(2)GPI. Increased beta(2)GPI:Ag and alpha beta(2)GPI were associated with a clinical history of thrombosis or recurrent fetal loss. The results of these investigations suggest that beta(2)GPI may play a role in the pathogenic mechanism of thrombosis associated with aPAs.

Type: Article
Title: Increased levels of beta(2) glycoprotein-I antigen and beta(2) glycoprotein-I binding antibodies are associated with a history of thromboembolic complications in patients with SLE and primary antiphospholipid syndrome
Keywords: beta(2)GPI, antiphospholipid antibodies, anti-beta(2)GPI antibodies, SLE, antiphospholipid syndrome, thrombosis, SYSTEMIC LUPUS-ERYTHEMATOSUS, BETA-2-GLYCOPROTEIN-I LEVELS, ANTICOAGULANT, CARDIOLIPIN, STANDARDIZATION, PHOSPHOLIPIDS, PROTHROMBIN, COAGULATION, THROMBOSIS, COFACTOR
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/85254
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